Upgrade Your NuCalm Journey to Clinical Strength.

We’ve spent decades upgrading NuCalm from a $5,995 FDA Class III medical device with extensive hardware into our simple, but incredibly powerful mobile app, and the optional biosignal processing disc for added clinical strength.

The NuCalm biosignal processing disc is an accessory to NuCalm. It is not the core neuroscience or therapeutic value of NuCalm. Paired with the foundational NuCalm mobile app, the discs increase the depth of the relaxation response of NuCalm. The NuCalm neuroacoustic software is available via monthly or annual subscription plans.

The NuCalm Biosignal Processing Disc

The NuCalm biosignal processing disc is a revolutionary delivery mechanism that activates the parasympathetic nervous system, by tapping into the body’s Pericardium Meridian with particular electromagnetic frequencies of inhibitory neurotransmitters to interrupt the HPA axis and downregulate sympathetic tone. The NuCalm biosignal processing discs are an important contributor to the clinical strength of NuCalm Rescue, PowerNap, and FlowState. Since the launch of NuCalm in 2009 as an FDA Class III medical device, the biochemistry has evolved in its delivery methods, strength, and efficacy; 2009 – 3 large chewable supplements and a cranial electrotherapy stimulation device; 2014 – a transdermal topical cream and a cranial electrotherapy stimulation device; 2019 – a biosignal processing disc, and nothing else. The impact of the disc ensures that each NuCalm (Rescue, FlowState, PowerNap) journey exhibits a predictable and safe:
  • Rapid induction of parasympathetic hypnagogic dissociative state
  • Sustained, steady parasympathetic dominance throughout the NuCalm journey
  • Rapid return to a functional state (motor skills, attention, and full cognition) with no lingering effects or mental lethargy


The biochemical signaling of the NuCalm clinical system includes a proprietary blend of inhibitory neurotransmitters, primarily GABA (Gamma-Aminobutyric Acid). GABA is the main inhibitory neurotransmitter in the central nervous system. GABAergic inhibition is seen at all levels of the CNS, including the hypothalamus, hippocampus, cerebral cortex, and cerebellar cortex. In addition to the large well established GABA pathways, GABA interneurons are abundant in the brain, with 50% of the inhibitory synapses in the brain being GABA mediated. In individuals with anxiety spectrum disorders or autonomic nervous system dysfunction these pathways are not optimally biologically functional. Anxiolytics will bind to the GABA receptors but do nothing to return the pathways to optimal function.

The NuCalm biosignal processing discs deliver the frequencies of GABA directly to the brain using resonance and biomodulation, like a tuning fork. This delivery mechanism overrides the body’s metabolic and absorption processes, including the challenge of penetrating the blood brain barrier. Every chemical has a signature frequency. Dr. Holloway worked with scientists in Germany and China for more than 4 years to identify the exact frequencies of the seven inhibitory neurotransmitters that were in the NuCalm transdermal cream. Once the specific frequencies were determined, it took over a year of trial and error and alchemy to adjust the frequency imprints to mimic the exact molecular formulation of the NuCalm transdermal cream. The NuCalm biosignal processing discs are then created by imprinting a signature frequency recipe inside a Tesla coil onto a six-layer Lakhovksy Multiwave Oscillator. The discs are protected from EMFs by being packaged in a Faraday bag.

Traditional Chinese Medicine explains that Qi (light energy) flows through the body along particular pathways, or Meridians, to maintain health. Everything in the world as we know it vibrates with a particular pattern, thus living systems produce electromagnetic frequencies endogenously that differ depending on the level of health or disease. It is hypothesized that if you can restore the frequencies that travel through the Meridians you can reinstate optimal physiology. Each NuCalm disc holds the electromagnetic frequency patterns of GABA and its precursors to deliver a pure biological signal to your body. When placed on the inside of your left wrist, at your Pericardium-6 acupuncture point, the disc sends a signal to the pericardium of your heart to activate local parasympathetic nerve fibers, which then transmit the signal to your brain telling it to increase vagal nerve output and begin the process of slowing down the body. The disc stops your acute stress response, so the brainwave entrainment with NuCalm’s patented neuroacoustic software is always reliable, fast acting, and efficient at getting you into Theta brain wave range, where cellular restoration and relaxation can take place.

Balancing the Brain’s Neurochemistry

A properly functioning GABAergic system is vital for relaxation, cellular restoration, and balance. NuCalm Rescue, PowerNap, and FlowState help reduce stress, promote recovery and generate calm by working at the root causes of the problem – the imbalanced neurochemical and neuroelectrical systems of the autonomic nervous system.

The brain’s chemical messengers or neurotransmitters are either excitatory, inhibitory or modulatory. The main excitatory neurotransmitter is glutamate, and its role is to potentiate signals forward and increase neuronal activity. The major inhibitory neurotransmitter, GABA, inhibits nerve activity by preventing signals from moving forward, thus calming the brain. It does this by interrupting the HPA and downregulating the secretion of adrenaline. The common neuromodulatory neurotransmitters are either serotonin or dopamine. Serotonin plays numerous important roles within the brain including regulating your mood, increasing your learning and memory, and is a chemical precursor for melatonin, an important sleep hormone. Dopamine is most well-known as the reward or pleasure chemical. Many studies have associated various neurological disorders with either the excess or deficit of a specific neurotransmitter. For example, increased dopamine levels have been found in people with addiction disorders, whereas decreased serotonin levels have been theorized to contribute to depression. Chronic stress is related to an improperly functioning GABAergic system that can no longer control the over-excitation and hyperactivity in the brain. Balance in neurochemical levels is the key to optimal brain health and function.

Get clinical grade results with the NuCalm biosignal processing discs.

Get the neuroscience of the 22nd century, today. The NuCalm biosignal processing discs provide the neurochemistry to accelerate the onset of the relaxation response, increase the depth of the experience, and prolong the physiological impact of Rescue, PowerNap, and FlowState.

Clinical strength NuCalm (Rescue, PowerNap, FlowState) using the NuCalm biosignal processing discs is recommended for the following NuCalmers:

  • Police, fire, EMTs, paramedics
  • Doctors, nurses
  • Active military and National Guard
  • Military veterans
  • Professional athletes, Olympic athletes, and high-level amateur athletes
  • Pilots, truck drivers, delivery drivers, and taxi drivers
  • Healing from a surgery or injury
  • Anyone with cancer, cardiovascular issues, MS, ALS, Parkinson’s Disease, neurological disorders, TBI, concussions, addiction, immunosuppressive diseases, ulcerative colitis, irritable bowel syndrome, Crohn’s disease, arthritis, ADHD, ADD, Asperger’s, seizures, migraines


The “clinical strength” NuCalm biosignal processing discs are only $4 per NuCalm use, compared to $23.75 per NuCalm use when it was an FDA Class III medical device. The discs are sold in packages of 20 or 100.

Here is the history of innovation to make NuCalm Rescue, PowerNap, and FlowState easier, more effective, and more affordable:

2009 – 2014: $23.75 per NuCalm use; 3 NuCalm chewable tablets and neuropatches for the cranial electrotherapy stimulation device

2014 – 2015: $17.50 per NuCalm use; 2 NuCalm chewable tablets and neuropatches for the cranial electrotherapy stimulation device

2015 – 2019: $19.75 per NuCalm use; transdermal cream and neuropatches for the cranial electrotherapy stimulation device

2019 – today: $4 per NuCalm use; a NuCalm biosignal processing disc

The Patented Biosignal Processing Disc 

Your body is an electrical conduit filled with conductive saline. Our Patented Biosignal Processing Discs create an electical feedback loop directly to your brain, using frequency resonance to calm your autonomic nervous system and prime your body and mind for recovery.

What’s in It?

Our Biosignal Processing Discs contain ZERO drugs. The design you see on the outside houses small bits of copper that hold an very light electrical charge.

How Does it Work?

When Applied to the Pericardium 6 accupressure point, the charge in the disc is activated by your body’s Gauss Field, the natural electromagnetic field that surrounds every human. Once activated, the disc produces a frequency that instructs your brain to begin creating the Neurotransmitter GABA.

Is It Safe?

Absolutely 100% Safe for pets, children, plants, or any living thing. The minute charge in the discs cannot shock you. GABA is already present in your body, and is safe at any level, its primary purpose is to supress your autonomic nervous system (stress response) and help you begin to relax.

To learn the complete science behind our patented Biosignal Processing Discs Click Here