The Neuroscience

The Neuroscience Behind NuCalm is Both Remarkable and Complex.

NuCalm: The Basics

Our company devoted more than 19 years inventing and developing the world’s most powerful neuroscience platform to manage brain wave function safely and predictably. We call it NuCalm.

Many leading scientists believe that all of creation in this dimension is oscillatory. Mankind has become desynchronized from the master oscillatory matrix. The greater the desynchronization the greater the alienation and sense of isolation. We bring, with NuCalm, to the world, a technology that can resynchronize and restore the lost complexity. NuCalm produces coherence in the heart, which is the true seat of intelligence. When the heart and brain connection is coherent even dormant DNA potentials are released.

In the invention process we focused on 4 critical areas of the brain: the reticular activating system, the corpus callosum, the HPA axis, and the autonomic nervous system. To create effective neurobiofeedback within the complexities of the brain, we leveraged the auditory motor cortex, not just as a gateway for collecting auditory signals, but for its function in stimulating the prefrontal and frontal motor cortex. The brain is nonlinear, thus using proprietary, complex methods to present patterns that the brain won’t easily get bored with represents a significant challenge. The binaural signal processing, frequency-following-response neurobiofeedback is foundational to the software but cannot be the only effective elements. We also used specific techniques to evoke potential on a cellular level and increase electrical output focused on certain brain regions.

We spent the past 14 years testing, clinically proving, refining, and simplifying complex neuroscience to produce an easy-to-use, safe, effective, and reliable platform that brings quick relief to people. For the many who have been part of the NuCalm family for years, they have observed our continuous innovation, from NuCalm 1.0 in 2009, to NuCalm 2.0 in 2016, and now NuCalm 3.0 since November 2021. Today, with NuCalm 3.0, we provide users, for the first time ever, the capability to change their mental state on demand: without drugs, without side effects, and without compromise.

NuCalm uses complex patented physics and algorithms built inside neuroacoustic software that lies underneath music. The software presents signals to the brain that pace brain wave frequencies higher or lower. To illustrate the complexity of the neuroacoustic software, let’s say a typical song is 5MB in size. One NuCalm neuroacoustic software journey is over 1,536 MB: that’s 307 times the size of a song. The complex method used to produce the neuroacoustic software is the ONLY patented method in the world, validated by over 5 years of research throughout the patent process showcasing that nothing like this has ever existed before, and the strength and efficacy of the outcomes are irrefutable. On August 17, 2021, NuCalm was awarded a patent for “methods and devices for applying dynamic, non-linear oscillations and vibrations” to elicit a physiological state change in a human being; U.S. Patent Registration No.: 11,090,459. This patent proved that NuCalm continues to stand alone as a true pioneer with the only technology that can do what we do – change your mental state on demand simply by listening to our neuroacoustic software.

NuCalm is safe, portable, and easy-to-use. It takes seconds to self-administer and within three minutes, you will experience parasympathetic nervous system dominance that results in homeostasis of your autonomic nervous system in one treatment. Rescue, PowerNap, and FlowState expedite recovery by oscillating your brain waves in the ‘healing zone’ of theta brain wave dominance, including the hypnagogic, dissociative state of cellular restoration. This results in a synchronization of the heart and lungs and lower respiration rates to one breath every 10 seconds. This synchronicity maximizes oxygenation throughout the brain and body which removes lactic acid, lowers inflammation, and increases focus through oxygen-rich red blood cells in the frontal cortex and prefrontal cortex. In as little as 20 minutes of Rescue, PowerNap, or FlowState, you will feel focused, energized, and able to perform at a high level without emotional distraction, fear, stress, or anxiety.

“Developing a beneficial meditation practice can take countless hours over a period of years. By using NuCalm I can effectively and quickly access a state of mind where I have the ability to respond instead of react. I use NuCalm because I have post-traumatic stress. With as little as 20 minutes a day I get to respond to my feelings and thoughts instead of react to them. When I have the ability to respond I can be humble, thoughtful, patient and kind. When I react instead of respond I can be aggressive, irritable and fearful. NuCalm aids me into being the version of myself that is genuine and real. It is who I am without PTS.”
– Magnus Johnson, former Special Forces Combat Veteran
“I use NuCalm every day and I have been for over 5 years. In fact, I feel like I’m at a disadvantage if I don’t use it. I call it my secret weapon and I’ve noticed with NuCalm in my life – I sleep better. I have less stress. I certainly have greater focus. And my focus has always been strong, but it’s definitely stronger. I have more mental alertness, greater levels of mental energy, and less brain fog. I have a deep sense of calm and peace. For me, peace of mind is high currency.”
– Jim Kwik, Renowned brain coach, podcaster, author, and entrepreneur
“The ability of NuCalm to reduce sympathetic discharge, and its impact on the autonomic nervous system, is clearly a freestanding and noteworthy contribution to society and our high-paced, stress-filled lives. We know that every organ system in the human body is disturbed when sympathetic tone predominates excessively and chronically. The sympathetic discharge associated with sleep deprivation and long working hours under stress allows opportunistic viruses and bacteria to colonize and challenge our system. When confronted with chronic inflammatory conditions, cancer, bacterial/viral infections, and other assaults to homeostasis, it becomes critical to optimize the immune system. NuCalm demonstrates the immune-boosting role of shifting to a parasympathetic-dominated tone.”– Tarman Aziz, MD, CCDS, CHC, Professor of Physiology and Neurology

Numerous physiological markers are available which provide data to analyze the efficacy of the NuCalm clinical system in decreasing the sympathetic nervous system response and anxiety. These markers include galvanic skin response, temperature, blood volume pulse, heart rate, heart rate variability (including HRV amp, SDNN, RMSSD, %LF, %HF, and LF/HF) and brain waves (including Beta, Alpha, Theta, and Delta amplitudes, Alpha/Theta crossover and slow cortical potentials). Each of these physiologic markers demonstrates a particular response (increase or decrease) under sympathetic and parasympathetic stimulation.

Galvanic skin response (GSR) is a method of measuring the electrical conductivity of the skin, which varies with its moisture level. This is notable because the eccrine glands are controlled by the sympathetic nervous system, so skin conductance is used as an indication of psychological or physiological arousal. There is a relationship between sympathetic activity and emotional arousal such as fear and anger. The GSR is highly sensitive to emotions in some people. Human eccrine glands receive primary signals from sympathetic cholinergic fibers that are controlled by the neurotransmitter acetylcholine. In measuring GSR, a very slight electrical current is run through the skin and changes in the salt and water in the sweat gland ducts are measured. The more emotionally aroused the subject is, the more active the sweat glands are and the greater the electrical conductivity of the skin. An increase in GSR occurs with sympathetic stimulation and decreases with parasympathetic stimulation.

Dermal temperature is another measure of sympathetic arousal. Dermal temperature decreases with sympathetic stimulation and increases with parasympathetic stimulation.

Blood volume pulse (BVP) is measured by photoplethysmography, which is a non-invasive transducer to measure the relative changes of blood volume in a subject’s finger or temple. An infrared light source is transmitted through or reflected off the tissue, detected by a phototransistor, and quantified in arbitrary units. Less light is absorbed when blood flow is greater, increasing the intensity of the light reaching the sensor. The wave form obtained from such a transducer represents the BVP of the subject, which is the phasic change in blood volume with each heartbeat. Heart rate is simply the number of beats of the heart per time interval. Heart rate increases with sympathetic stimulation and decreases with parasympathetic stimulation. The BVP likewise increases with sympathetic stimulation and decreases with parasympathetic stimulation.

Heart rate variability (HRV) consists of beat-to-beat differences in intervals between successive heartbeats. In general, emotional stress gives rise to heart rhythm patterns that appear irregular and erratic. The heart rate variability waveform under stress appears as a series of uneven, jagged peaks (i.e., an incoherent heart rhythm pattern). Physiologically, this pattern indicates that the signals produced by the two branches of the autonomic nervous system are out of sync with each other. This incoherent pattern of physiological activity associated with stressful emotions can cause the body to operate inefficiently, deplete energy, and produce extra wear- and-tear on the body. This is especially true if emotional stress is prolonged or frequent. During positive emotions, the heart rhythm pattern becomes highly ordered, appearing like a smooth, harmonious wave. This is called a coherent heart rhythm pattern. With coherent heart rhythm, the activity in the two branches of the autonomic nervous system is synchronized and the body’s systems operate with increased efficiency and harmony.

HRV data can identify anxiety and stressful influences on the cardiovascular system. The interbeat interval is a portal through which parasympathetic and sympathetic influences may be observed. HRV is a measure of the variation of the beat-to-beat interval. Increased HRV has been shown to have positive clinical significance, whereas reduced HRV has been associated with negative clinical outcomes and conditions. Variation in the beat-to-beat interval is a physiological phenomenon resulting from several different inputs to the sinoatrial node, which is the impulse-generating, pacemaker tissue located in the right atrium of the heart, and thus the generator of normal sinus rhythm. The main inputs are the sympathetic and the parasympathetic nervous systems. The two primary fluctuations are respiratory arrhythmia and low-frequency oscillations. Respiratory arrhythmia is associated with the respiratory rate and low-frequency oscillations are associated with Mayer waves of blood pressure (waves in arterial blood pressure brought about by oscillations in baroreceptor and chemoreceptor reflex control systems).

The most widely used methods for measuring HRV are time-domain methods and frequency-domain methods. The time-domain methods are based on the beat-to-beat or NN intervals, which are analyzed in a variety of ways. Included among these are the SDNN (the standard deviation of NN intervals) and the RMSSD (the square root of the mean squared difference of successive NNs). These are measures representing sympathetic or parasympathetic influence. Increased scores of these measures represent greater parasympathetic influence. Norms for these measures are: RMSSD 27.2 +/- 12.3 and SDNN 136.5 +/- 33.4.

Measurements assessed with frequency-domain methods include LF, LF norm, HF, HF norm, and LF/HF ratio. HRV rhythms in the low frequency (LF) range (between 0.04 to 0.15Hz) reflect mixed sympathetic and parasympathetic activity. Mental stress increases LF activity and is usually considered a marker of sympathetic modulation. The high frequency (HF) range (between 0.15 to 0.4Hz) contains rhythms regulated by parasympathetic activity and corresponds to N-N variations caused by respiration. Deep, even breathing activates the parasympathetic nervous system and raises the amplitude of HF. Mental stress decreases HF activity. Vagal activity is the major contributor to the HF component. With the LF/HF ratio, high numbers mean dominance of sympathetic activity while low numbers mean dominance of the parasympathetic activity. After deep and even breathing, an increase reflects changes in the parasympathetic regulation. HRV decreases with sympathetic stimulation and increases with parasympathetic stimulation. Consistent with this result, the HRV LF% and the LF/HF ratio increase with sympathetic stimulation and decrease with parasympathetic stimulation.

Various brain waves are associated with states of wakefulness and sleep, mental activity related to cognitive, sensory, and motor activities, and emotions such as fear and anxiety. Beta brain waves are the most rapid brain waves and reflect normal waking consciousness. Beta amplitudes increase with sympathetic stimulation. There is a range of Beta waves: low Beta, relaxed but alert (~13–15Hz), mid Beta, which is the learning zone (~15–19Hz), and high beta, which is the anxious brain (associated with fear and anxiety) exhibiting brain wave frequencies ~23–38Hz. Alpha waves indicate a comfortable, relaxed state, 8–12Hz, and are associated with relaxation, meditation, and idleness. Theta waves reflect a deeply relaxed state and cellular restoration, 4–7Hz. Delta waves are indicative of the sleep state wherein signals are moving through clusters of neurons very slowly, around 4Hz. Delta amplitude progressively decreases during sleep. Delta waves are related to V waves, which occur during sleep, and to slow cortical potentials.

The production of Alpha and Theta patterns in the brain is correlated to the relaxation response. The relaxation response reduces heart rate and blood pressure, relaxes muscles, and increases oxygen to the brain. The relaxation response is extremely beneficial to learning and problem solving and is accompanied by Alpha (higher amplitude, lower frequency brain waves) and theta rhythms (even greater amplitude, lower frequency brain waves). The brain wave frequencies increase with sympathetic stimulation and decrease with parasympathetic stimulation.

Alpha to Theta crossover occurs just at pre-sleep, providing a dissociative hypnagogic experience of profound relaxation. Alpha to theta crossover is where people experience restorative sleep and the loss of a sense of time and place. It is called the healing zone or psychological dissociative state. This state of consciousness is similar to a meditative or hypnotic relaxed state. The Alpha-Theta crossover state is a deeply relaxed state in the Alpha (8-12Hz) and the Theta (4-7Hz) range, right on the edge of sleep. The name comes from the behavior of the brain waves. Alpha waves are usually higher in amplitude, or more powerful, than Theta. Alpha-Theta crossover is when the amplitude of the Alpha waves drops and the Theta amplitude rises to the point where it crosses over the Alpha waves, indicating it has become more powerful. Alpha-Theta crossovers decrease with sympathetic stimulation and increase with parasympathetic stimulation.

Slow cortical potentials (SCPs) are gradual changes in the membrane potentials of cortical dendrites which are in the frequency range below 1–2Hz that last from 300ms to several seconds. Negative potential shifts indicate mobilization or higher excitability, positive SCP shifts represent reduced excitability or inhibition of neuronal activity. Slow cortical potential shifts in the electrical negative direction reflect the depolarization of large cortical cell assemblies, reducing their excitation threshold. SCPs increase with sympathetic stimulation and decrease with parasympathetic stimulation.

Imagine having the power of your brain in the palm of your hand. Since the dawn of humankind, humans have either discovered or created various ways to manage their mental state. Today, if you want more energy you can drink a coffee, a Red Bull, a Monster Energy drink, or more; if you want to feel sedated you can drink alcohol; if you want to escape your problems, you can use recreational drugs; if you don’t want to feel depressed, you can take anti-depressants; if you don’t want to feel anxious, you can take anti-anxiety drugs; or if you are having difficulty falling asleep, you can take sleeping pills. All these methods to change your mental state can be effective in the short term, but all have long-term side effects and negative consequences. But now there is a better way!

A NuCalm Overview by the Inventor, Dr. Blake Holloway

NuCalm Research Studies

Brain Wave Frequencies

What are brain wave frequencies and how does NuCalm work with them?

The brain consists of millions of brain cells forming trillions of connections. These building blocks of the brain, called neurons, communicate with each other through chemical and electrical signals. When masses of neurons send synchronized pulses, they oscillate and produce a wave-like effect or a brain wave. Brain wave frequency is measured in Hertz (Hz) or cycles per second. Higher order brain activity will produce high-frequency brain waves, such as beta or gamma waves. When we are awake, talking and in a normal working consciousness, we are in the beta brain wave frequency. As shown in the chart, human brain waves oscillate in a frequency range of 0.5Hz – 41Hz, and include 5 categories (delta > theta > alpha > beta > gamma).

Many people spend too much time in higher frequencies associated with stress, fear, anxiety, and worry. This frequency range elicits the stress hormone, cortisol along with adrenaline and makes it difficult to down regulate the stress response, called the sympathetic nervous system. On the other side of the stress response is the rest and digest response, called the parasympathetic nervous system. This aspect of the autonomic nervous system is critical for balance, good health, and wellbeing, lowering inflammation, improving immune strength, and increasing resilience. The challenge for people is how to stop the stress response reliably and safely.

NuCalm’s patented technology uses complex physics, mathematics, and algorithms built into a software that lies beneath music. This neuroacoustic software presents the brain with a signal via the auditory motor cortex, and the brain follows the signal. The key NuCalm channels for activating the parasympathetic nervous system are Rescue, PowerNap, and FlowState. These channels slow down brain waves into Alpha and then hold them in an oscillating pattern of Theta (4Hz – 7Hz). Theta is known as the healing zone because when your brain is in theta, the cells do their maintenance and clean toxins out of the cells, and the mitochondria (cell’s energy source) is restored. Theta activity is associated with light REM sleep, dreaming, meditation, deep restoration, and the replenishment of hormone reservoirs. Alpha activity is associated with relaxation, greater awareness, and the production of serotonin, a mood balancing hormone. The Alpha-Theta crossover state is a combination of both Alpha and Theta brain wave frequencies, where you experience hypnogogic dissociation (loss of time and space), and all the therapeutic benefits of cellular restoration can take place. Rescue, PowerNap, and FlowState predictably guide brain wave frequencies to the healing zone every time you use them.

During a Rescue, PowerNap, or FlowState journey, the brain will dip into Delta, especially if the person is sleep deprived, but NuCalm’s main goal is to get the person into a state right above deep sleep. This is the optimal recovery zone of the mind and body, and spending enough time in this state every day is essential to our health. This is the state where the parasympathetic nervous system replenishes our body’s resources that were depleted from stress, fear, anxiety, and worry, which causes sympathetic overload. Typically, people describe their Rescue, PowerNap, or FlowState journey as being aware of their surroundings while simultaneously feeling like they are in a deep sleep with slowed breathing, lower heart rate, a heaviness to the body, a wandering mind, but no bodily movement.

Because NuCalm slows your brain waves, so fast and so reliably, your body is able to receive many of the benefits of restorative sleep without actually being asleep. According to research at Harvard Medical School, you get over 2 hours of restorative sleep in just 20 minutes with NuCalm.

The Patented NuCalm Neuroacoustic Software

The science behind NuCalm’s neuroacoustic software is remarkable and complex. The objectives behind inventing the new NuCalm neuroacoustic software platform were to design physiological outcomes focused on recover, restore, reboot, and rebalance… like fine tuning a musical instrument. Dr. Blake Holloway spent several years immersed in the intriguing and exotic arenas of quantum biology and neurophysics. New discoveries in neuroscience over the past decade allowed him to develop NuCalm 3.0, a neuroacoustic physics file that is faster acting, provides a deeper recovery and cellular restoration experience, and predictably balances the mind and body, compared to NuCalm 1.0 (launched in 2009) and NuCalm 2.0 (launched 2016).

Many leading scientists, including Dr. Holloway, believe that all of creation on this dimension is oscillatory. Mankind has become desynchronized from the master oscillatory matrix. The greater the desynchronization the greater the alienation and sense of isolation. We bring, with NuCalm, to the world, a technology that can resynchronize and restore the lost complexity. NuCalm Rescue, PowerNap, and FlowState produce coherence in the heart, which is the true seat of intelligence. When the heart and brain connection is coherent even dormant DNA potentials are released.

In the invention process Dr. Holloway focused on 4 critical areas of the brain: the reticular activating system, the corpus callosum, the HPA axis, and the autonomic nervous system. To create effective neurobiofeedback within the complexities of the brain, Dr. Holloway leveraged the auditory motor cortex, not just as a gateway for collecting auditory signals, but for its function in stimulating the prefrontal and frontal motor cortex. The brain is nonlinear, thus using proprietary, complex methods to present patterns that the brain won’t easily get bored with represents a significant challenge. The binaural signal processing, frequency-following-response neurobiofeedback and isochronic wave form are foundational to the neuroacoustic software but cannot be the only effective elements. Dr. Holloway also used specific techniques to evoke potential on a cellular level and increase electrical output focused on certain brain regions. These are spikes in brain electrical activity observed in response to the presentation of an auditory stimulus. Multiple stimuli delivered a certain number of times per second, mimicking the desired brain frequency level, can create evoked potentials in the brain at that same frequency level.

To create an auditory evoked response at a frequency range between 12Hz – 4Hz (Alpha and Theta), is difficult because human ears cannot receive sounds delivered under 20Hz. This is where the brain’s compensatory mechanisms leveraging binaural signal processing come into play. This method involves simultaneously delivering two tones with different frequencies into the left and right ears, for example, 250Hz to left ear, and 255Hz to right ear. These sound waves will initially meet in the superior olivary complex, a structure in the brainstem, where they will interfere constructively and create a resultant beat frequency calculated by the difference between the two tones’ frequencies (255Hz – 250Hz = 5Hz beat frequency, which is Theta).

The beat frequency at any level can then be transmitted to and perceived by the auditory cortex of the brain. Repeated presentations of binaural signal processing and isochronic wave forms create repetitive auditory evoked potentials which induce a frequency following response in the brain, meaning multiple neural networks will begin oscillating at that specific beat frequency. This brain wave synchronization has been verified in electroencephalography and quantitative electroencephalography studies conducted by Dr. Holloway and NuCalm’s independent medical advisory board of 52 leading doctors, research scientists, and academicians.

To illustrate the complexity of the neuroacoustic software, let’s say a typical song is 5MB in size. One NuCalm neuroacoustic software journey is over 1,536 MB: that’s 307 times the size of a song. The complex method used to produce the neuroacoustic software is the ONLY patented method in the world, validated by over 5 years of research throughout the patent process showcasing that nothing like this has ever existed before, and the strength and efficacy of the outcomes are irrefutable. On August 17, 2021, NuCalm was awarded a patent for “methods and devices for applying dynamic, non-linear oscillations and vibrations” to elicit a physiological state change in a human being; U.S. Patent Registration No.: 11,090,459. This patent proved that NuCalm continues to stand alone as a true pioneer with the only technology that can do what it does – change your mental state on demand simply by listening to neuroacoustic software.

The key to the NuCalm Rescue and PowerNap achieving their intended outcome of creating deep, fast, predictable, and safe relaxation and cellular restoration is the technology’s ability to pace the brainwave function in a pattern of Alpha and Theta. Alpha brainwave is 12Hz to 8Hz and synonymous with relaxation, creativity, and being “in the zone.” Theta is the powerful healing zone for humans and cycles between 7Hz and 4Hz. Theta is just above dreamless deep sleep and is the only time the body cleans and removes toxins out of its cells and the cell’s energy source (mitochondria) is restored. Theta represents parasympathetic nervous system dominance (rest and digest side of the autonomic nervous system) and is manifested in deep diaphragmatic breathing. In deep Theta, your heart and lungs are synchronized to a respiration rate of one breath every 10 seconds and six breaths per minute. This diaphragmatic breathing is integral to healing as it creates high levels of oxygen rich red blood cells that permeate the entire body including the neocortex of the brain.

So why is there so much information and physics inside the NuCalm neuroacoustic software? Because the brain is exceptionally complex and dynamic. Using non-linear oscillations, NuCalm’s patented method significantly improves the entrainment process by activating and consuming the attention of the brain’s reticular activating system. In addition to cleansing and occupying the reticular activating system, the neuroacoustic software uses the auditory motor cortex to elicit activity across the corpus callosum, the frontal cortex, and the motor cortex. The corpus callosum is the bridge between the left (analytical) and right (creative) hemispheres of the brain – NuCalm Rescue and PowerNap clean up the information flow between the hemispheres. The reticular activating system is the brain’s “fiber optic” cable of stimulation to the brain – NuCalm commands its full attention and filters it by using non-linear oscillations. The frontal cortex is the brain’s cognitive functioning and reasoning. By increasing oxygen rich red blood cell flow, Rescue, PowerNap, and FlowState open new neuronal pathways in the brain, creating greater clarity and creativity. The hippocampus is the brain’s memory center. By increasing oxygen rich red blood cell flow, Rescue, PowerNap, and FlowState open new neuronal pathways in the hippocampus and allow for conflict resolution and the ability to resolve bad memories by separating the emotion from the context of the memory. The neuroacoustic software also relaxes the motor cortex, which creates global relaxation of the mind and body.

All of these physiological outcomes are accomplished using physics to elicit specific neuronal activities while activating the vagus nerve. As previously mentioned, the NuCalm neuroacoustic software activates and commands the full attention of the reticular activating system by using non-linear oscillations and vibration. The brain is easily seduced by visual and/or auditory stimulation, and it quickly tries to identify patterns so it can find short cuts. The non-linear oscillations command the brain’s attention, while the non-linear algorithm does not allow the brain to recognize the pattern. This important complexity results in NuCalm never losing its efficacy. The brain will never figure out the pattern, thus it will never build resistance to NuCalm, no matter which channel you choose, from DeepSleep to Ignite. NuCalm will work every time you use it, there are no diminished returns.

The creation of the NuCalm neuroacoustic software goes beyond Dr. Holloway’s invention of the world’s most sophisticated and powerful auditory physics. We also have to create a good listening experience for the NuCalm user. The soundtrack process is sophisticated, precise, and time consuming. Dan Selene and his team have to work within the confines of the frequency and pitch matrix of the physics. Meaning that each note has to be in congruence with the pitch and frequency of the physics or we would be creating resistance to the physiological outcome. As an example of the detail considered in each neuroacoustic software track, the first release of NuCalm 2.0, NuCalm Rescue in July 2016 contained the following to support and enhance the efficacy of the neuroacoustic software: original musical compositions, music licensed from a world-renowned guitarist, holophonic 3D recordings of night sounds at a vortex in Sedona, AZ as well as sunrise at the ocean in Big Sur, CA. Holophonic is a binaural recording system based on the claim that the human auditory system acts as an interferometer. It relies on phase variance, just like stereophonic sound. The sound characteristics of holophonics are most clearly heard through headphones, though they can be effectively demonstrated with two-channel stereo speakers, provided that they are phase-coherent. The word “holophonics” is related to “acoustic hologram.”

The NuCalm neuroacoustic software development process is part creative artistry and part complex science. The scientific process involves meticulously creating music to match the physics of the binaural signal processing and isochronic wave form frequency-following response neuroacoustic software developed by Dr. Holloway. Each segment of music is specifically matched to the time signatures of the pitch and frequency matrix and non-linear oscillations of the underlying physics. The NuCalm Rescue journeys focus on the Solfeggio 528Hz ‘miracle tone’ with a tropical paradise environment and specially tuned instrumentation. Each NuCalm Rescue neuroacoustic software journey has between 23 and 54 discreet tracks interwoven to create a magical, restorative listening experience like people have never heard before.

Solfeggio tones create music to calm an overactive mind and 528Hz, often referred to as the “miracle tone,” or “love frequency,” resonates at the heart of everything. It connects your heart, your spiritual essence, to the spiraling reality of heaven and earth. The love frequency is the “Miracle” note of the original Solfeggio musical scale. Independently confirmed by researchers, these core creative frequencies were used by ancient priests and healers in advanced civilizations to manifest miracles and produce blessings. The original sound frequencies of the Solfeggio scale were used in ancient Gregorian chants but were “lost” centuries ago. The chants and the electro-magnetic frequencies of this scale were believed to enhance the spiritual experience of those hearing the notes. The sacred Solfeggio Scale was rediscovered in 1974 by Dr. Joseph Puleo through a series of events that some may call miracles. He was guided to the Pythagorean method of numerical reduction which led to his deciphering of the frequency of these notes as hidden in the text of the book, Numbers. Math scientist Victor Showell describes 528 as fundamental to the ancient Pi, Phi, and the Golden Mean evident throughout natural design. Victor Showell and John Stuart Reid have proven that 528 is essential to the sacred geometry of circles and spirals consistent with DNA structuring and hydrosonic restructuring. 528 resolves to a 6, the icon for physical manifestation. That is, 5+2+8=15; and 1+5=6 (using Pythagorean math). The symbol “6” reflects the “spiraling down from heaven into the wholeness of earth.” In fact, the love frequency can be fundamental to broadcasting all matter and energy into reality according to the laws of physics.

This frequency brings transformation as the process of DNA reparation is followed by beneficial effects – increased amount of life energy, clarity of mind, awareness, awakened or activated creativity, ecstatic states like deep inner peace, dance and celebration. Through music and physics, NuCalm is activating your imagination, intention, and intuition for you to operate at your highest and best purpose.

“Alpha waves in the human brain are between 6 and 8 hertz. The wave frequency of the human cavity resonates between 6 and 8 hertz. All biological systems operate in the same frequency range. The human brain’s alpha waves function in this range and the electrical resonance of the earth is between 6 and 8 hertz. Thus, our entire biological system – the brain and the earth itself – work on the same frequencies. If we can control that resonate system electronically, we can directly control the entire mental system of humankind.”
– Nicola Tesla

The Autonomic Nervous System

The autonomic nervous system (ANS) controls the involuntary bodily functions – pupillary response, heart rate, respiration, digestion, and sexual arousal. The autonomic nervous system is composed of the sympathetic nervous system (stress response) and the parasympathetic nervous system (rest and digest response). The ANS manages human stress, fear, anxiety, depression, and worry, in addition to the fight-or-flight-or-freeze response. In humanity’s ancient past, the fight-or-flight response played an essential role in helping to keep our ancestors alive in the face of such dangers as predatory animals and natural occurrences such as earthquakes, floods, and volcanic eruptions. Researchers have discovered that actual physical danger is not necessary to trigger the fight-or-flight response. It can also be triggered by our thoughts and beliefs. Simply put, if you habitually focus on thoughts and beliefs of a limiting or negative nature, you are causing your body to act as if it is in danger. This results in the chronic production of stress hormones, specifically cortisol.

Stress is a biological response to the stimulus of a threat, either real or perceived. During an acute stress response, two parallel pathways are activated to prepare the body for fight-or-flight, the sympathetic adreno-medullary (SAM) arm of the autonomic nervous system and the HPA axis. Both systems can be triggered in a bottom-up manner from the brainstem by critical homeostatic perturbations, like respiratory distress, pain, or inflammation – which pose real threats. They can also be triggered in a top-down fashion from the limbic system, particularly from the amygdala, by psychogenic stressors, either innate or experiential – perceived threats. Your thoughts can trigger this response, and often do. The SAM triggers the release of epinephrine (adrenaline) and norepinephrine (noradrenaline) from the adrenal medulla into the bloodstream.

As these hormones circulate through the body, respiratory rate and heart rate accelerate and blood pressure increases to maximize the delivery of oxygenated blood to vital organs. This alerts the body to speed up, tense up, become hypervigilant, and take action for survival. In parallel, the HPA axis (The Hypothalamus-Pituitary-Adrenal axis) triggers a series of hormonal signals to maintain this state of hyper-alertness. The hypothalamus releases corticotropin-releasing factor (CRF), which signals the anterior pituitary gland, to release adrenocorticotropic hormone (ACTH). This hormone travels to the adrenal glands, prompting them to release cortisol, the well-known stress hormone. The release of cortisol can increase the production of epinephrine, as well as trigger the glucose release from protein to supply the body with energy.

Once this happens, blood vessels that supply oxygen and nutrients to our body’s cells and organs are constricted so that more blood can be made available to nourish the tissues of our body’s major muscle groups, especially in our arms and legs, since it is primarily these extremities that the body uses to fend off external attacks and get out of harm’s way. Prior to this response, the blood in the body is concentrated in what are known as the abdominal visceral organs. These include our adrenal glands, kidneys, liver, gallbladder, stomach, intestines, colon, and appendix – the organs responsible for digestion and absorption of foods and nutrients, excretion, and various other functions that provide for proper cell growth and production of cellular energy. As blood is rushed to the tissues of the arms and legs, the visceral organs cannot function at 100%, causing all growth-related activities in the body to become limited. If this process continues for sustained periods of time, our body’s overall functioning is compromised, and we begin to break down. Once the fight-or-flight adrenaline response is activated, the mind cannot rationalize itself or self-regulate until the threat is removed and time passes, because the amygdala has taken oxygen rich red blood cells from the frontal cortex, negating access to executive function, logic, and decision making.

When there aren’t any threats, the HPA axis is in what might be described as “idle mode.” This state of idleness allows the rest of our body to flourish the way that nature intended. And the way nature intended for all humans is to be in autonomic nervous system balance, where we exhibit sympathetic nervous system responses throughout the day, but also activate the rest and digest restoration of the parasympathetic nervous system.

Chronically elevated stress hormones result in chronically suppressed immune function, leading to greater susceptibility to infectious disease. Additionally, because of how the visceral organs are also negatively impacted by chronic stress, many of our body’s functions are also suppressed, setting the stage for impaired digestion, increased muscle tension, and eventual declines in cell and tissue function, which can lead to a wide range of diseases, including cardiovascular disease and cancer. In addition, stress is also a major risk factor for gastrointestinal disorders, skin problems, neurological and emotional disorders, and a variety of conditions related to immune dysfunction, ranging from the common cold to arthritis, herpes, and even AIDS. Chronic stress in middle-age can also play a role in triggering the onset of Alzheimer’s disease and dementia decades later, most likely because of the way chronic stress negatively impacts the brain and hormone regulation.

Sleep disorders are another area where stress is involved. To achieve healthy sleep our body’s normal cycle of hormone production must operate efficiently, especially regarding cortisol. When we are healthy, cortisol levels are highest in the morning (6-8 AM) and lowest in the evening, where they continue at a low level as we fall asleep. This allows our body to release sleep enhancing hormones, such as melatonin and serotonin, leading to deep, restful sleep. Stress interferes with this process. When we are stressed, cortisol levels remain high, even into the night, preventing restful sleep. Over time, the cycle of cortisol production becomes unbalanced, and even reversed, with levels spiking in the evening and falling in the morning, resulting in feelings of exhaustion. Insomnia and restless sleep (awakening throughout the night) are both common examples of sleep disorders that are associated with nighttime spikes in cortisol and other stress hormones, including, in some cases, adrenaline. Stress compromises the amount and quality of restorative sleep. This important phase of sleep (Theta brain waves) is when our cells remove toxins and restore our mitochondria, which is our cell’s energy source. Prolonged lack of restorative sleep decreases your cellular health and increases your risk of disease.

Stress, more than anything else, has the greatest potential to sabotage every aspect of our life. Our health, our relationships, our work, our productivity, our brain function, and cognitive abilities, and even our ability to simply enjoy our day can all be negatively impacted by stress. Yet, despite all that we know about the importance of managing stress, as a society we seem more stressed than ever before, especially with COVID-19.

So, what can we do about stress? Well, the first thing we can do is to accept it, appreciate it, and understand that stress is real, stress impacts every human on Earth every day, and the human physiological response as described above is the same in each of us. No one is impregnable to stress, so we must address it. Many people seek yoga, Tai Chi, meditation, or deep breathing exercises as healthy pathways to managing stress and activating the parasympathetic nervous system. Many others manage stress through the consumption of drugs and/or alcohol. All these approaches have an impact on slowing down the human stress response, but as most of us know, the path of drugs and alcohol has negative consequences that lead to more stress and depreciation of the mind and body.

But there is also another path to managing stress, and this one is founded in applied neuropsychobiology, has no drugs, no side effects, and is easy to use. NuCalm was invented out of necessity by the brilliant quantum physicist, neuroscientist, Dr. Blake Holloway. Dr. Holloway served the military veteran community in San Antonio, Texas for more than 40 years. His invention path began over 33 years ago, which illustrates the challenges inherent in trying to solve complex problems such as down regulating the sympathetic tone (stress response) with predictability, reliability, safety, and ease for people suffering from Post-Traumatic Stress, often comorbid with addiction.

Janet Hranicky, MD, PhD, and Dr. Michael Galitzer have been studying the benefits of NuCalm on stage IV metastatic cancer patients using HRV since October 2014. The need to slow down cortisol, sympathetic overload, and adrenal fatigue is paramount to helping cancer patients battle the disease and heal. NuCalm has proven to slow down the sympathetic nervous system while increasing parasympathetic nervous system dominance. Below please find research observations by Dr. Hranicky:

“NuCalm allows the old limbic area of the brain to experience a state of perceived safety and comfort, which triggers a parasympathetic response and the chemical changes physiologically connected with it. When the old brain is calm and feels safe, the frontal cortex can experience synchronicity and flow throughout the entire organism, and allow the person to go into a state of deep relaxation. Perhaps, deeper than they might have gone for a long, long time. That state, we know, is a healing state. Going into and having periods of deep, restorative rest and relaxation is hugely important for getting better, getting well, and for creating optimal health and well-being. For most patients, there has been a chronic stress physiology involved with cancer, both before the diagnosis and then, for sure, secondary to having a diagnosis. The NuCalm state of deep relaxation allows for recuperation and a reboot of the system that can provide the resiliency necessary to come back to where regeneration can occur. Regeneration occurs when we can bring down the stress physiology, because the immune system, the hormonal system, all of the healing mechanisms will begin to buoy back up and begin to self-regulate again.”

The goal of NuCalm Rescue, PowerNap, or FlowState is not to heal or cure disease, but to simply guide brain wave function into a state of healing (theta), where the body activates its maintenance and detoxification systems. The body knows how to heal itself and get into homeostasis, it’s the “monkey mind” that overrides the body’s natural balance and keeps the foot on the accelerator. NuCalm puts the brakes on, and provides valuable “resource allocation” of valuable oxygen rich red blood cells. When the “fight-or-flight” response is activated, oxygen-rich red blood cells flow from the prefrontal and frontal cortex to the primordial midbrain, also referred to as the “reptilian brain,” managed by the amygdala. The prefrontal and frontal cortex of the human brain is what separates humans from every other species on Earth. This is where our character, personality, patience, presence, thoughts, emotions, decision making, and executive functions occur. The autonomic nervous system and primordial midbrain manages fear, stress, anxiety, depression, worry, and our fight-or-flight. Therefore, when we are stressed, resources are allocated and trapped inside fear, stress, anxiety, depression, and worry, and we often find it difficult to access our personality, character, patience, presence, and rational decision making. This is what makes humans react to stressors instead of responding to them in a rational, patient manner.

Mindful practices and drugs and alcohol help interrupt the stress response by diverting resources away from the fight-or-flight response and down-regulating the sympathetic tone. The challenges with mindful practices are as great as the benefits derived … meditation, for example, requires time, effort, patience, persistence, determination and is difficult to engage in when our “monkey mind” is racing and we are in a high stress state. Furthermore, the intangible of meditation (we can’t see it, touch it, taste it, smell it, or hear it) leaves a mystery in our minds as we engage on our meditation journey. The challenges with drugs and alcohol are far more detrimental due to the risks of addiction and the physical consequences of systematic abuse.

NuCalm is safe, portable, and easy-to-use. It takes seconds to self-administer and within three minutes, you will experience parasympathetic nervous system dominance that results in homeostasis of your autonomic nervous system in one treatment. Rescue, PowerNap, and FlowState expedite recovery by oscillating your brain waves in the ‘healing zone’ of Theta brain wave dominance, including the hypnagogic, dissociative state of cellular restoration. This results in a synchronization of the heart and lungs and lower respiration rates to one breath every 10 seconds. This synchronicity maximizes oxygenation throughout the brain and body which removes lactic acid, lowers inflammation, and increases focus through oxygen-rich red blood cells in the frontal cortex and prefrontal cortex. In as little as 20 minutes of Rescue, PowerNap, or FlowState, you will feel focused, energized, and able to perform at a high level without emotional distraction, fear, stress, or anxiety.

“We are measuring the impact of NuCalm on human physiology and concussion healing using heart rate measurement and heart rate variability (HRV). We look for enhancing the vagal tone, which reflects the parasympathetic system (rest and relaxation) response. Heart rate variability is the easiest way to evaluate the vagal response. Although other expressions of stress response are certainly present such as pupillary dilation, increased heart rate, increased respiratory rate and increased concentrations of cortisol and catecholamines, the measure of HRV has become our Gold Standard in evaluating concussion healing. The PNS plays a major role in immunity and response to inflammation. It is therefore important in recovery from brain injury healing since the inflammatory response following concussion is responsible for the post-concussive symptoms. We have been researching the impact of NuCalm on concussion patients – measuring the response versus a sham. Thus far, the results have been significant. NuCalm enhances the parasympathetic state, which is clearly beneficial in post-concussive recovery.”
– Dr. Tom Allen (former Dean of the University of Oklahoma Medical School). Professor, Center of Exercise and Sports Medicine, Adjunct Professor of Biostatistics and Epidemiology, and the Director, Human Performance Laboratory, School of Medicine at the University of Oklahoma, Tulsa.

The NuCalm Biosignal Processing Disc

The NuCalm biosignal processing disc is a revolutionary delivery mechanism that activates the parasympathetic nervous system, by tapping into the body’s Pericardium Meridian with particular electromagnetic frequencies of inhibitory neurotransmitters to interrupt the HPA axis and downregulate sympathetic tone. The NuCalm biosignal processing discs are an important contributor to the clinical strength of NuCalm Rescue, PowerNap, and FlowState. Since the launch of NuCalm in 2009 as an FDA Class III medical device, the biochemistry has evolved in its delivery methods, strength, and efficacy; 2009 – 3 large chewable supplements and a cranial electrotherapy stimulation device; 2014 – a transdermal topical cream and a cranial electrotherapy stimulation device; 2019 – a biosignal processing disc, and nothing else. The impact of the disc ensures that each NuCalm (Rescue, FlowState, PowerNap) journey exhibits a predictable and safe:

Rapid induction of parasympathetic hypnagogic dissociative state
Sustained, steady parasympathetic dominance throughout the NuCalm journey
Rapid return to a functional state (motor skills, attention, and full cognition) with no lingering effects or mental lethargy

The biochemical signaling of the NuCalm clinical system includes a proprietary blend of inhibitory neurotransmitters, primarily GABA (Gamma-Aminobutyric Acid). GABA is the main inhibitory neurotransmitter in the central nervous system. GABAergic inhibition is seen at all levels of the CNS, including the hypothalamus, hippocampus, cerebral cortex, and cerebellar cortex. In addition to the large well established GABA pathways, GABA interneurons are abundant in the brain, with 50% of the inhibitory synapses in the brain being GABA mediated. In individuals with anxiety spectrum disorders or autonomic nervous system dysfunction these pathways are not optimally biologically functional. Anxiolytics will bind to the GABA receptors but do nothing to return the pathways to optimal function.

The NuCalm biosignal processing discs deliver the frequencies of GABA directly to the brain using resonance and biomodulation, like a tuning fork. This delivery mechanism overrides the body’s metabolic and absorption processes, including the challenge of penetrating the blood brain barrier. Every chemical has a signature frequency. Dr. Holloway worked with scientists in Germany and China for more than 4 years to identify the exact frequencies of the seven inhibitory neurotransmitters that were in the NuCalm transdermal cream. Once the specific frequencies were determined, it took over a year of trial and error and alchemy to adjust the frequency imprints to mimic the exact molecular formulation of the NuCalm transdermal cream. The NuCalm biosignal processing discs are then created by imprinting a signature frequency recipe inside a Tesla coil onto a six-layer Lakhovksy Multiwave Oscillator. The discs are protected from EMFs by being packaged in a Faraday bag.

Traditional Chinese Medicine explains that Qi (light energy) flows through the body along particular pathways, or Meridians, to maintain health. Everything in the world as we know it vibrates with a particular pattern, thus living systems produce electromagnetic frequencies endogenously that differ depending on the level of health or disease. It is hypothesized that if you can restore the frequencies that travel through the Meridians you can reinstate optimal physiology. Each NuCalm disc holds the electromagnetic frequency patterns of GABA and its precursors to deliver a pure biological signal to your body. When placed on the inside of your left wrist, at your Pericardium-6 acupuncture point, the disc sends a signal to the pericardium of your heart to activate local parasympathetic nerve fibers, which then transmit the signal to your brain telling it to increase vagal nerve output and begin the process of slowing down the body. The disc stops your acute stress response, so the brainwave entrainment with NuCalm’s patented neuroacoustic software is always reliable, fast acting, and efficient at getting you into Theta brain wave range, where cellular restoration and relaxation can take place.

Balancing the Brain’s Neurochemistry

A properly functioning GABAergic system is vital for relaxation, cellular restoration, and balance. NuCalm Rescue, PowerNap, and FlowState help reduce stress, promote recovery and generate calm by working at the root causes of the problem – the imbalanced neurochemical and neuroelectrical systems of the autonomic nervous system.

The brain’s chemical messengers or neurotransmitters are either excitatory, inhibitory or modulatory. The main excitatory neurotransmitter is glutamate, and its role is to potentiate signals forward and increase neuronal activity. The major inhibitory neurotransmitter, GABA, inhibits nerve activity by preventing signals from moving forward, thus calming the brain. It does this by interrupting the HPA and downregulating the secretion of adrenaline. The common neuromodulatory neurotransmitters are either serotonin or dopamine. Serotonin plays numerous important roles within the brain including regulating your mood, increasing your learning and memory, and is a chemical precursor for melatonin, an important sleep hormone. Dopamine is most well-known as the reward or pleasure chemical. Many studies have associated various neurological disorders with either the excess or deficit of a specific neurotransmitter. For example, increased dopamine levels have been found in people with addiction disorders, whereas decreased serotonin levels have been theorized to contribute to depression. Chronic stress is related to an improperly functioning GABAergic system that can no longer control the over-excitation and hyperactivity in the brain. Balance in neurochemical levels is the key to optimal brain health and function.